We Was Somebody

As the number of people who inject drugs (PWID) in Philadelphia increases, more healthcare professionals find themselves treating patients suffering from IV drug addictions. Unfortunately, many of these busy healthcare professionals have little education on the biochemistry of addiction and obstacles between people who inject drugs (PWID) and their recovery. We Was Somebody, a fictional play inspired by the stories of PWID in Kensington, Philadelphia, aims to promote understanding and empathy for the complexity of addiction and ultimately improve the quality of healthcare provided to the human beings affected by it. The content of the play comes from peer-reviewed scientific literature, personal interviews with counsellors and psychiatrists, and anecdotes from PWID. The fictional narrative format protects the anonymity of those still living in the Kensington area while preserving the integrity of their experiences; recurring themes from their stories became cornerstones of the play. Furthermore, a play proved the most effective way to distill two years of observations, experiences, and relationships into a digestible two-hour presentation for medical students and healthcare professionals. We Was Somebody illustrates how communities can fail PWID, veterans, and the homeless. It debunks the myth that addiction is a moral failure. It addresses how we as a society hypocritically condemn addicts who use to cope with disease or trauma, yet we ignore professionals and students who use to cope with the emotional and physical stress of their work. Most importantly, We Was Somebody forces the audience to see addicts as people first. The results of this project successfully raise awareness of this marginalized population to the audience. For some viewing healthcare professionals and medical students, it may reshape their prejudice against PWID. Regardless, simply initiating empathetic conversations within the medical community about this prevalent issue will improve future quality of and access to healthcare for PWID

Valuable assets: phase 2 of a general formal investigation into the role and status of classroom assistants in Scotland's secondary and special schools

The aim of this research is to extend existing data by considering classroom assistants in secondary and special schools in Scotland. The research examines the work and employment of classroom assistants and in particular explores the reasons for any role stretch amongst this group

12 Tips to Guarantee a Fragmented (Absolutely Terrible) Curriculum in a Time of Crisis

Medical education scholarship is filled with articles focused on rigorous curriculum design and innovation. In the midst of a public health crisis, the authors aim to provide a reflective guide to curriculum development focused on curriculum gone wrong. The authors propose twelve recommendations that will bring all educators closer to curricular failure

Domestic Widgets: Leveraging Household Creativity in Co-Creating Data Physicalisations

The home environment is a complex design space, especially when it has multiple inhabitants. As such, the home presents challenges for the design of smart products. Householders may be different ages and have differing interests, needs, and attitudes towards technology. We pursued a research-through-design study with family households to envision and ‘co-create’ the future of data-enabled artifacts for their homes. We have iteratively developed domestic research artefacts for these households that are open, data-enabled, physical visualizations. These artefacts - called Domestic Widgets - are customisable in their design and functionality throughout their lifespan. The development process highlights design challenges for sustained co-creation and the leveraging of household creativity in (co-creation) research toolkits. These include the need to allow and inspire iterative customization, the need to accommodate changing roles within the home ecology, and the aim that such design should be inclusive for all family members (irrespective of age and technical proficiency), whilst maintaining a role and purpose in the home. We invite the RTD community to critically discuss our, and other, open and iterative end-user designs for sustained co-creation. By presenting unbuilt and interactive pre-built Domestic Widgets, we interactively foster engagement with practises of sustained co-creation

You Can\u27t Take it With You Dramaturgical Website

The presenters are enrolled in TheatreUNI’s Dramaturgy course where they study drama through a theoretical lens to create analytical criticism and research contextual support for TheatreUNI’s current productions. They have compiled research into a dramaturgical website focused on topics relating to the text of Kaufman and Hart’s Pulitzer Prize winning play You Can’t Take it With You. We will be presenting our final website designed for TheatreUNI patrons, and discussing each of the topics that we individually researched. Our research covers the following topics through the lens of the 1930’s: Great Depression, entertainment industry, music, fashion, immigration, the Russian Revolution, Rasputin, and the Romonovs, the public’s views of the IRS, the FBI, use of fireworks, comedic styles, and racism present in the original text and how TheatreUNI is overcoming it

The Angola Gyre is a hotspot of dinitrogen fixation in the South Atlantic Ocean

© The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Marshall, T., Granger, J., Casciotti, K. L., Dahnke, K., Emeis, K.-C., Marconi, D., McIlvin, M. R., Noble, A. E., Saito, M. A., Sigman, D. M., & Fawcett, S. E. The Angola Gyre is a hotspot of dinitrogen fixation in the South Atlantic Ocean. Communications Earth & Environment, 3(1), (2022): 151, https://doi.org/10.1038/s43247-022-00474-x.Biological dinitrogen fixation is the major source of new nitrogen to marine systems and thus essential to the ocean’s biological pump. Constraining the distribution and global rate of dinitrogen fixation has proven challenging owing largely to uncertainty surrounding the controls thereon. Existing South Atlantic dinitrogen fixation rate estimates vary five-fold, with models attributing most dinitrogen fixation to the western basin. From hydrographic properties and nitrate isotope ratios, we show that the Angola Gyre in the eastern tropical South Atlantic supports the fixation of 1.4–5.4 Tg N.a−1, 28-108% of the existing (highly uncertain) estimates for the basin. Our observations contradict model diagnoses, revealing a substantial input of newly-fixed nitrogen to the tropical eastern basin and no dinitrogen fixation west of 7.5˚W. We propose that dinitrogen fixation in the South Atlantic occurs in hotspots controlled by the overlapping biogeography of excess phosphorus relative to nitrogen and bioavailable iron from margin sediments. Similar conditions may promote dinitrogen fixation in analogous ocean regions. Our analysis suggests that local iron availability causes the phosphorus-driven coupling of oceanic dinitrogen fixation to nitrogen loss to vary on a regional basis.This work was supported by the South African National Research Foundation (114673 and 130826 to T.M., 115335, 116142 and 129320 to S.E.F.); the US National Science Foundation (CAREER award, OCE-1554474 to J.G., OCE-1736652 to D.M.S. and K.L.C., OCE-05-26277 to K.L.C.); the German Federal Agency for Education and Research (DAAD-SPACES 57371082 to T.M.); the Royal Society (FLAIR fellowship to S.E.F.); and the University of Cape Town (T.M., J.G., S.E.F.). The authors also recognize the support of the South African Department of Science and Innovation’s Biogeochemistry Research Infrastructure Platform (BIOGRIP)

Evaluation at scale of microbiome-derived metabolites as biomarker of flavan-3-ol intake in epidemiological studies.

The accurate assessment of dietary intake is crucial to investigate the effect of diet on health. Currently used methods, relying on self-reporting and food composition data, are known to have limitations and might not be suitable to estimate the intake of many bioactive food components. An alternative are nutritional biomarkers, which can allow an unbiased assessment of intake. They require a careful evaluation of their suitability, including: (a) the availability of a precise, accurate and robust analytical method, (b) their specificity (c) a consistent relationship with actual intake. We have evaluated human metabolites of a microbiome-derived flavan-3-ol catabolite, 5-(3',4'-dihydroxyphenyl)-[gamma]-valerolactone (gVL), as biomarker of flavan-3-ol intake in large epidemiological studies. Flavan-3-ols are widely consumed plant bioactives, which have received considerable interest due to their potential ability to reduce CVD risk. The availability of authentic standards allowed the development of a validated high-throughput method suitable for large-scale studies. In dietary intervention studies, we could show that gVL metabolites are specific for flavan-3-ols present in tea, fruits, wine and cocoa-derived products, with a strong correlation between intake and biomarker (Spearman's r = 0.90). This biomarker will allow for the first time to estimate flavan-3-ol intake and further investigation of associations between intake and disease risk

Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake

Abstract: Data from dietary intervention studies suggest that intake of (−)-epicatechin mediates beneficial vascular effects in humans. However, population-based investigations are required to evaluate associations between habitual intake and health and these studies rely on accurate estimates of intake, which nutritional biomarkers can provide. Here, we evaluate a series of structurally related (−)-epicatechin metabolites (SREM), particularly (−)-epicatechin-3′-glucuronide, (−)-epicatechin-3′-sulfate and 3′-O-methyl-(−)-epicatechin-5-sulfate (SREMB), as flavan-3-ol and (−)-epicatechin intake. SREMB in urine proved to be a specific indicator of (−)-epicatechin intake, showing also a strong correlation with the amount of (−)-epicatechin ingested (R2: 0.86 (95% CI 0.8l; 0.92). The median recovery of (−)-epicatechin as SREMB in 24 h urine was 10% (IQR 7–13%) and we found SREMB in the majority of participants of EPIC Norfolk (83% of 24,341) with a mean concentration of 2.4 ± 3.2 µmol/L. Our results show that SREMB are suitable as biomarker of (−)-epicatechin intake. According to evaluation criteria from IARC and the Institute of Medicine, the results obtained support use of SREMB as a recovery biomarker to estimate actual intake of (−)-epicatechin